Identification of Potential Biomarkers for Ryanodine Receptor 1 (RYR1) Mutation-Associated Myopathies Using Bioinformatics Approach

Figure 3

Network analysis of DEGs. (a) Protein-protein interaction network constructed with the differentially expressed genes. Red indicates that gene expression is upregulated; blue indicates that gene expression is downregulated. (b–d) Top 15 genes with the highest MCC, Degree, and Closeness. (e) UpSet diagram summarizing overlapped genes in three sections. (f) Venn diagram of hub genes and skeletal muscle-specific expressed gene overlap.

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