Integrated Bioinformatics and Clinical Correlation Analysis of Key Genes, Pathways, and Potential Therapeutic Agents Related to Diabetic Nephropathy

Figure 1

Flowchart of the study. GSE30528 and GSE1009 were defined as training datasets to screen DEGs, and the intersection was taken as common DEGs to perform functional enrichment analysis. The common DEGs were used to construct PPI network and identify the top 10 hub genes of DN. GSE96804 and GSE47183 were defined as external validation datasets to verify the gene expression profiles of the screened hub genes. The clinical correlation analysis and drug-gene interaction analysis were performed to validate the clinical significance and potential targeted drugs of hub genes associated with DN.