Elevated Serum IGFBP-2 and CTGF Levels Are Associated with Disease Activity in Patients with Dermatomyositis

Table 2

Spearman correlations of IGFBPs with disease activity assessed by MITAX.

			IGFBP1		IGFBP2		IGFBP3		IGFBP4		IGFBP6		CTGF
Characteristics	Subgroup patients	Sample size		value		value		value		value		value		value
Constitutional	All DM patients	64	0.472	<0.001	0.260	0.038	-0.078	0.540	0.226	0.072	-0.010	0.939	0.247	0.049
	DM-non-ILD	32	0.446	0.011	0.326	0.069	-0.191	0.295	0.302	0.093	-0.017	0.926	0.299	0.097
	DM-ILD	32	0.508	0.003	0.168	0.357	0.059	0.750	0.123	0.502	-0.016	0.929	0.180	0.325
Cutaneous disease activity	All DM patients	64	0.270	0.031	0.257	0.040	-0.346	0.005	0.026	0.837	0.063	0.622	0.233	0.064
	DM-non-ILD	32	0.227	0.211	0.108	0.557	-0.161	0.377	0.265	0.142	-0.010	0.958	0.427	0.015
	DM-ILD	32	0.365	0.040	0.436	0.013	-0.471	0.007	-0.157	0.392	0.158	0.387	0.070	0.704
Skeletal disease activity	All DM patients	64	0.054	0.672	-1.330	0.293	0.142	0.264	0.001	0.992	-0.136	0.284	0.011	0.929
	DM-non-ILD	32	0.134	0.463	-0.093	0.612	0.059	0.748	0.013	0.946	-0.083	0.650	-0.003	0.986
	DM-ILD	32	-0.052	0.779	-0.190	0.299	0.190	0.299	0.010	0.955	-0.176	0.336	-0.017	0.925
Gastrointestinal disease activity	All DM patients	64	0.415	0.001	0.330	0.008	-0.104	0.411	0.188	0.136	-0.067	0.598	0.134	0.290
	DM-non-ILD	32	0.385	0.030	0.160	0.382	0.003	0.987	0.264	0.144	-0.276	0.126	0.220	0.226
	DM-ILD	32	0.461	0.008	0.479	0.006	-0.151	0.410	0.170	0.352	0.161	0.377	0.038	0.838
Pulmonary disease activity	All DM patients	64	0.169	0.181	0.135	0.287	0.105	0.407	0.300	0.016	0.080	0.531	0.049	0.698
	DM-non-ILD	32	0.254	0.161	-0.184	0.314	0.070	0.704	0.212	0.244	-0.108	0.556	0.129	0.483
	DM-ILD	32	0.420	0.017	0.338	0.058	-0.046	0.803	0.391	0.027	0.061	0.742	0.130	0.480
Cardiovascular disease activity	All DM patients	64	0.367	0.030	0.184	0.145	-0.071	0.578	0.263	0.036	0.052	0.683	0.229	0.069
	DM-non-ILD	32	0.517	0.002	0.331	0.064	-0.079	0.666	0.4050.405	0.021	0.126	0.493	0.322	0.073
Muscle disease activity	All DM patients	64	0.406	0.001	0.336	0.007	-0.087	0.493	0.094	0.458	-0.079	0.536	0.192	0.128
	DM-non-ILD	32	0.496	0.004	0.249	0.169	-0.161	0.379	0.174	0.342	-0.038	0.837	0.220	0.226
	DM-ILD	32	0.382	0.031	0.481	0.005	0.075	0.684	0.225	0.216	0.014	0.940	0.191	0.294
Global disease activity	All DM patients	64	0.584	< 0.001	0.380	0.002	-0.183	0.147	0.280	0.025	0.014	0.915	0.292	0.019
	DM-non-ILD	32	0.589	< 0.001	0.261	0.150	-0.164	0.368	0.386	0.029	-0.053	0.772	0.394	0.026
	DM-ILD	32	0.629	< 0.001	0.478	0.006	-0.203	0.266	0.176	0.336	0.077	0.674	0.113	0.537

Bold fonts indicate statistical significance.