Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via TGF-<i>β</i>1/Smad Signaling

<div>I-125 seed irradiation suppresses cell proliferation, migration, and invasion of PLC and Huh7. (a) Cell viability of PLC and Huh7 cells was evaluated after 24 h of incubation with I-125 seed irradiation at varied doses (0, 2, 4, 6, and 8 Gy). Migration capabilities of PLC and Huh7 cells with the treatment of 0 and 4 Gy I-125 irradiation was assessed with wound healing assay (b) and migration assay (c). Invasive capabilities of PLC and Huh7 cells with the treatment of 0 and 4 Gy I-125 irradiation was assessed with Transwell assay (d). The average number of invasive cells was calculated by counting the number of cells in 5 fields per chamber. 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Disease Markers

fig2

Figure 2

Figure 2: Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via TGF-<i>β</i>1/Smad Signaling 

Figure 2 | Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via TGF-β1/Smad Signaling 