Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via TGF-<i>β</i>1/Smad Signaling

<div>I-125 seed irradiation inhibits the TGF-<i>β</i>1 signaling pathway. (a) RT-PCR assay demonstrated that the I-125 seed radiation downregulate the expression of TGF-<i>β</i>1, Smad2, and Snail. (b). WB assay demonstrated that the I-125 seed radiation downregulate the expression of TGF-<i>β</i>1, p-Smad2, and p-Smad3. (c) By immunofluorescence staining, the I-125 seed irradiation downregulates the expression of TGF-<i>β</i>1 in PLC and Huh7 cells, respectively (data of the immunofluorescence for Smad2, p-Smad2, Smad3, and p-Smad3 not shown, bar: 20 <i>μ</i>m). (d) Relative protein expression of the genes in PLC. (e) Relative protein expression of the genes in Huh7. 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Disease Markers

fig4

Figure 4

Figure 4: Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via TGF-<i>β</i>1/Smad Signaling 

Figure 4 | Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via TGF-β1/Smad Signaling 