Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via TGF-<i>β</i>1/Smad Signaling

<div>TGF-<i>β</i>1 activator reverse I-125 seed irradiation inhibitory effects on the EMT and TGF-<i>β</i>1 signaling pathway. TGF-<i>β</i>1 activator reverses the inhibitory role in migration (a) and invasion (b) of PLC and Huh7. TGF-<i>β</i>1 activator reverses the roles in the EMT and TGF-<i>β</i>1 signaling pathway-related markers by WB assay (c) and immunofluorescence assay for PLC (d) and for Huh7 (e) and their relative IOD (integrated optical density) per cell were plotted, respectively (f). The average number of invasive cells was calculated by counting then number of cells in 5 fields per chamber. 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Disease Markers

fig5

Figure 5

Figure 5: Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via TGF-<i>β</i>1/Smad Signaling 

Figure 5 | Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via TGF-β1/Smad Signaling 