Research Article
Moxifloxacin Induced Liver Injury by Causing Lachnospiraceae Deficiency and Interfering with Butyric Acid Production through Gut–Liver Axis
Figure 2
Hepatic injury was appraised using liver injury correlative serum biochemical indicators and histopathological observation. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), alkaline phosphatase (ALP), superoxide dismutase (SOD), and malondialdehyde (MDA) levels in rats were detected on days 3, 7, 14, and 21 of moxifloxacin (MXF) treatment (). Representative pathological images of hematoxylin and eosin (H&E) staining under light microscopy revealed fatty degeneration in hepatic cells, which presented as fat vacuoles (black arrow), in MXF–treated rats (magnification: 10x).