Moxifloxacin Induced Liver Injury by Causing <i>Lachnospiraceae</i> Deficiency and Interfering with Butyric Acid Production through Gut–Liver Axis

<div>TUNEL analysis and immunofluorescence of the expression of cleaved caspase–3 in rats’ liver tissues with moxifloxacin- (MXF-) induced liver injury on day 7 of treatment, when liver damage was most severe. Liver tissues were stained with TUNEL reaction to reveal cells undergoing DNA fragmentation (a). Sections of liver tissues were processed for TUNEL assay to detect apoptosis of the liver. Nuclei were stained with DAPI (blue), and the section undergoing TUNEL assay was stained in green. Magnification: 100x. The expression of cleaved caspase–3 in liver tissues was observed by a fluorescence microscope (b). Cleaved caspase–3 (green) and DAPI staining (blue), as well as merged pictures, are presented. Magnification: 100x.</div>

Disease Markers

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Figure 3: Moxifloxacin Induced Liver Injury by Causing <i>Lachnospiraceae</i> Deficiency and Interfering with Butyric Acid Production through Gut–Liver Axis 

Figure 3 | Moxifloxacin Induced Liver Injury by Causing Lachnospiraceae Deficiency and Interfering with Butyric Acid Production through Gut–Liver Axis 