Moxifloxacin Induced Liver Injury by Causing Lachnospiraceae Deficiency and Interfering with Butyric Acid Production through Gut–Liver Axis

Figure 4

Metabonomic analysis and metabolic changes in rats with moxifloxacin- (MXF-) induced liver injury on day 7 of treatment, when liver damage was most severe. (a) The fold changes of 40 polar and nonpolar metabolites were identified. , upregulated metabolites; , downregulated metabolites. (b) The metabolites with mutual reaction relationships were visualized, and these relationships involved seven metabolic pathways. The red nodes denote the upregulation of metabolite abundance, the blue nodes denote the downregulation of metabolite abundance, and the yellow nodes represent metabolites with no significant changes. Red edges represent the enzymes that have been activated for two metabolites. Blue edges represent the enzymes that have been inactivated for two metabolites. Black edges represent the metabolite ratios have direct relationships but no significant changes. Metabolites with no direct relationships were linked by dotted lines.

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