Moxifloxacin Induced Liver Injury by Causing Lachnospiraceae Deficiency and Interfering with Butyric Acid Production through Gut–Liver Axis

Figure 8

Interaction network of metabonomic profiles, the gut microbiota, and the indirect pathway of the gut–liver axis in moxifloxacin–induced hepatotoxicity. Oxidative phosphorylation, lipid metabolism, and butanoate metabolism are the main metabolic pathways affected by moxifloxacin. The variations of gut flora, represented by a heightened abundance of Muribaculaceae and the decline abundance of Lachnospiraceae, led to the observed changes in intestinal metabolic function. Muribaculaceae and Lachnospiraceae participate in the reduction of butyric acid production and alteration in lipid metabolism could be closely related to the pathophysiological changes of liver function.