Clinicopathological Significance of STAT3 and p-STAT3 among 91 Patients with Adenocarcinoma of the Esophagogastric Junction

Table 1

Immunohistochemical staining for the correlation between STAT3/p-STAT3 expression and clinical features of AEG.

Clinical features	Patients ()	STAT3 expression			p-STAT3 expression
		(−)	(+)		(−)	(+)
		13	48		24	37
Gender				0.156			0.763
Male	46	12	34		19	27
Female	15	1	14		5	10
Age (year)				1.000			0.601
≥60	38	8	30		16	22
<60	23	5	18		8	15
Differentiation				0.757			1
High+medium	27	5	22		11	16
Low	34	8	26		13	21
pT				0.069			0.01
pT1+ pT2	28	9	19		16	12
pT3+ pT4	33	4	29		8	25
pN				0.117			0.001
−	25	8	17		16	9
+	36	5	31		8	28
pTNM				0.027			0.004
pI + pII	34	11	23		19	15
pIII	27	2	25		5	22

: test, Fisher’s exact test; STAT3: signal transduction and activators of transcription factor 3; p-STAT3: phosphorylated signal transduction and activators of transcription factor 3; AEG: adenocarcinoma of the esophagogastric junction; pT: tumor invasion; pN: lymph node metastasis; pTNM: tumor stage.