Clinicopathological Significance of STAT3 and p-STAT3 among 91 Patients with Adenocarcinoma of the Esophagogastric Junction

Table 3

Univariate analysis with respect to the 5-year survival of the patients with AEG.

Clinical features	Patients	5-year survival (%)
	61	Patients	Rate (%)
		25	41.0
Gender				0.487
Male	46	18	39.1
Female	15	7	46.7
Age(year)				0.717
<60	23	9	39.1
≥60	38	16	42.1
Differentiation				0.028
Well+ moderately	27	15	55.6
Poorly	34	10	29.4
pT				0.410
pT1+ pT2	28	13	46.4
pT3	33	12	36.4
pN				0.001
−	25	17	68.0
+	36	8	22.2
pTNM				0.048
pI+ pII	34	18	52.9
pIII	27	7	25.9
Chemotherapy				0.807
No	18	8	44.4
Yes	43	17	39.5
Radiotherapy				0.965
No	46	19	41.3
Yes	15	6	40.0
STAT3				0.168
Low	13	7	53.8
High	48	18	37.5
p-STAT3				0.001
Low	24	16	66.7
High	37	9	24.3

: log-rank test; AEG: adenocarcinoma of the esophagogastric junction; STAT3: signal transduction and activators of transcription factor 3; p-STAT3: phosphorylated signal transduction and activators of transcription factor 3; pT: tumor invasion; pN: lymph node metastasis; pTNM: tumor stage.