lncRNA-DANCR Promotes Taxol Resistance of Prostate Cancer Cells through Modulating the miR-33b-5p-LDHA Axis

Figure 1

DANCR contributes to Taxol resistance of PCa. (a) Expressions of lncRNA-DANCR from prostate tumors and normal prostate tissues were analyzed by http://ualcan.path.uab.edu from TCGA database. (b) Expressions of lncRNA-DANCR from prostate tumors () and adjacent normal tissues () were analyzed by qRT-PCR. (c) Expressions of DANCR were examined in two non-tumorous prostate cell lines and four PCa cell lines. (d) PC3 and LN96 cells were transfected with control siRNA or DANCR siRNA for 48 hours. Expression of DANCR was detected. (e and f) The above cells were subjected to cell proliferation assay at 0, 24 h, 48 h, and 72 h by MTT assay. (g) Cell migration of the above transfected cells were examined by wound healing assay. (h and i) PC3 and LN96 cells without and with DANCR knockdown were treated with Taxol. Cell viability was examined by MTT assay. , , and .

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