Research Article

Neutrophil Transcriptional Deregulation by the Periodontal Pathogen Fusobacterium nucleatum in Gastric Cancer: A Bioinformatic Study

Table 3

36 link genes shared by F. nucleatum-stimulated DEGs in neutrophils and gastric cancer candidate genes.

Gene IDGeneAdjusted valueLog fold change

DNAJB1DnaJ heat shock protein family (Hsp40) member B10.003-2.13
EHD1EH domain-containing 10.0111.16
IER2Immediate early response 20.016-0.75
SMARCE1SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily e, member 10.016-3.25
GRIK1-AS2///BACH1GRIK1 antisense RNA 2///BTB domain and CNC homolog 10.0161.17
RAB5ARAB5A, member RAS oncogene family0.0180.76
RYBPRING1 and YY1 binding protein0.022-0.81
P4HBProlyl 4-hydroxylase subunit beta0.022-0.99
UQCR11Ubiquinol-cytochrome c reductase, complex III subunit XI0.022-0.96
HSPE1Heat shock protein family E (Hsp10) member 10.026-1.42
ATP5JATP synthase, H+ transporting, mitochondrial Fo complex subunit F60.027-1.07
RRAGCRas-related GTP binding C0.027-0.67
ARFIP1ADP ribosylation factor interacting protein 10.0281.06
B3GALT2Beta-1,3-galactosyltransferase 20.028-3.68
UBE2HUbiquitin conjugating enzyme E2 H0.0300.90
GNB1G protein subunit beta 10.0340.62
SETD5SET domain-containing 50.0370.74
GALR2Galanin receptor 20.039-2.76
TNPO3Transportin 30.039-2.70
TM9SF2Transmembrane 9 superfamily member 20.039-0.73
UBR4Ubiquitin protein ligase E3 component n-recognin 40.0400.69
CANXCalnexin0.0410.69
WNK1WNK lysine deficient protein kinase 10.042-0.83
BMPR2Bone morphogenetic protein receptor type 20.043-3.06
DICER1Dicer 1, ribonuclease III0.043-0.71
ARGLU1Arginine and glutamate rich 10.046-0.84
MOAP1Modulator of apoptosis 10.046-1.43
AFTPHAftiphilin0.0460.62
GARSGlycyl-tRNA synthetase0.047-0.75
RABGAP1LRAB GTPase activating protein 1-like0.049-0.95
SHBSH2 domain-containing adaptor protein B0.0492.33
PBX1PBX homeobox 10.049-2.33
PCM1Pericentriolar material 10.050-2.29
GMFGGlia maturation factor gamma0.050-0.45
TRAF3TNF receptor-associated factor 30.0500.93
LYNLYN protooncogene, Src family tyrosine kinase0.0500.46

Genes are ranked by adjusted values for F. nucleatum-stimulated DEGs in neutrophils.