A Novel Serum Biomarker Model to Discriminate Aortic Dissection from Coronary Artery Disease

Table 3

Diagnostic performance of FLUTHE in patients with AD vs. CAD in discovery set and validation set in different time manners.

Time manners	Sen	Spe	Accuracy	PPV	NPV	PLR	NLR
Discovery set
≤72 h	0.723	0.952	0.803	0.986	0.417	15.06	0.29
>72 h	0.652	0.905	0.837	0.714	0.877	6.86	0.38
Validation set
≤72 h	0.765	0.813	0.776	0.928	0.52	4.07	0.29
>72 h	0.954	0.905	0.931	0.913	0.92	10.04	0.05

AD: aortic dissection; CAD: coronary artery disease; NLR: negative likelihood ratio; NPV: negative predictive value; PLR: positive likelihood ratio; PPV: positive predict value; Sen: sensitivity; Spe: specificity; FLUTHE: prediction index including TF, sFe, LDL, HDL, uric acid, and eGFR. Optimal threshold value was obtained from the data, which was the threshold leading to the maximum summation of sensitivity and specificity (i.e., the Youden index).