ATF3 Regulates Osteogenic Function by Mediating Osteoblast Ferroptosis in Type 2 Diabetic Osteoporosis

<div>ATF3 mediated HG-induced ferroptosis by inhibiting system Xc<sup>-</sup> function. (a) Relative ATF3 mRNA and SLC7A11 mRNA levels were assayed using RT-qPCR. (b) Western blot showed increased level of ATF3 protein and decreased level of SLC7A11 protein under HG condition. (c) Relative level of glutamate release was assayed. (d) Assessment of GSH levels in different conditions. (e) Expression of ATF3 protein and SLC7A11 protein measured by western blot in NG, HG, and erastin group. (f) Alizarin Red S staining in NG, HG, and erastin group. 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Disease Markers

fig6

Figure 6

Figure 6: ATF3 Regulates Osteogenic Function by Mediating Osteoblast Ferroptosis in Type 2 Diabetic Osteoporosis 