Serum Uric Acid Is Associated with the Progression of Left Ventricular Diastolic Dysfunction in Apparently Healthy Subjects

Table 2

Changes in echocardiography parameters during follow-up grouped by quartiles of serum uric acid.

SUA (μmol/L)		≤282	283~340	341~393	≥394	value
		272	269	273	268
LA, mm	B		^‡	^‡	^‡	<0.001
	F		^‡	^‡	^‡	<0.001
						0.580
LVESD, mm	B		^‡	^‡	^‡	<0.001
	F		^‡	^‡	^‡	<0.001
						0.792
LVEDD, mm	B		^‡	^‡	^‡	<0.001
	F		^‡	^‡	^‡	<0.001
						0.012
LVESV index, mL/m^2	B					0.070
	F					0.044
						0.181
LVEDV index, mL/m^2	B					0.450
	F					0.244
						0.240
LV mass index, g/m^2	B				^†	0.003
	F				^‡	0.001
						0.231
IVST, mm	B		^‡	^‡	^‡	<0.001
	F		^‡	^‡	^‡	<0.001
						0.381
LVPWT, mm	B		^‡	^‡	^‡	<0.001
	F		^†	^‡	^‡	<0.001
						0.453
RWT	B					0.121
	F					0.208
						0.145
LVEF, %	B					0.008
	F					0.140
	Δ					0.708
E, cm/s	B					0.132
	F				^‡	<0.001
					^‡	<0.001
A, cm/s	B					0.737
	F					0.959
						0.660
E/A	B					0.057
	F					0.211
						0.138
e septal, cm/s	B					0.166
	F				^‡	<0.001
					^†	0.005
e lateral, cm/s	B					0.186
	F				^‡	<0.001
					^†	<0.001
E/e septal	B					0.179
	F				^†	0.003
					^‡	<0.001
E/e lateral	B					0.257
	F					0.009
					^‡	<0.001
E/e average	B					0.175
	F				^†	0.003
					^‡	<0.001

Data are expressed as or median (interquartile range). , ^†, ^‡. B: baseline; : changes in corresponding parameters; F: follow-up; IVST: interventricular septal thickness; LA: left atrium; LV: left ventricle; LVEDD: left ventricular end-diastolic diameter; LVEDV: left ventricular end-diastolic volume; LVEF: left ventricular ejection fraction; LVESD: left ventricular end-systolic diameter; LVESV: left ventricular end-systolic volume; LVPWT: left ventricular posterior wall thickness; RWT: relative wall thickness; SUA: serum uric acid.