Research Article
Serum Uric Acid Is Associated with the Progression of Left Ventricular Diastolic Dysfunction in Apparently Healthy Subjects
Table 3
Univariate and multivariate regression analysis for LVDD progression.
| | Variate | Univariate | Multivariate (SUA as continuous variable) | Multivariate (SUA as categorical variable) | | OR (95% CI) | | OR (95% CI) | | OR (95% CI) | |
| | Age, per 10 y | 2.466 (2.138~2.864) | <0.001 | 2.740 (2.330~3.249) | <0.001 | 2.839 (2.406~3.379) | <0.001 | | Male sex | 1.908 (1.462~2.503) | <0.001 | — | — | — | — | | BMI, per kg/m2 | 1.027 (0.982~1.075) | 0.242 | — | — | — | — | | Systolic BP, per 10 mmHg | 1.232 (1.122~1.357) | <0.001 | — | — | — | — | | Diastolic BP, per 10 mmHg | 1.221 (1.063~1.406) | 0.005 | 1.143 (1.003~1.304) | 0.046 | 1.147 (1.006~1.310) | 0.041 | | Hypertension | 2.638 (1.581~4.431) | <0.001 | | | | | | Diabetes | 2.595 (1.852~3.648) | <0.001 | 1.776 (1.079~2.939) | 0.024 | 1.676 (1.016~2.783) | 0.044 | | Smoking | 1.461 (1.067~2.000) | 0.018 | — | — | — | — | | HbA1c, per 1% | 1.688 (1.380~2.088) | <0.001 | 0.771 (0.577~1.023) | 0.073 | 0.792 (0.589~1.055) | 0.114 | | Fasting glucose, per mmol/L | 1.230 (1.105~1.381) | <0.001 | — | — | — | — | | Fasting insulin, per μU/L | 1.002 (0.992~1.013) | 0.638 | — | — | — | — | | HOMA-IR, per unit | 1.002 (0.973~1.027) | 0.880 | — | — | — | — | | Triglyceride, per mmol/L | 1.436 (1.255~1.659) | <0.001 | 1.440 (1.233~1.705) | <0.001 | 1.425 (1.219~1.690) | <0.001 | | Total cholesterol, per mmol/L | 0.954 (0.844~1.077) | 0.444 | — | — | — | — | | HDL cholesterol, per mmol/L | 0.361 (0.243~0.530) | <0.001 | — | — | — | — | | LDL cholesterol, per mmol/L | 0.911 (0.788~1.051) | 0.202 | — | — | — | — | | eGFR, per 10 mL/min/1.732 m2 | 0.750 (0.685~0.818) | <0.001 | — | — | — | — | | LVEF, per 1% | 0.942 (0.909~0.976) | <0.001 | 0.919 (0.881~0.959) | <0.001 | 0.917 (0.879~0.957) | <0.001 | | Beta blocker | 1.889 (1.114~3.208) | 0.018 | — | — | — | — | | ACEI/ARB | 2.403 (1.380~4.239) | 0.002 | — | — | — | — | | Calcium channel blocker | 3.038 (1.489~6.465) | 0.003 | — | — | — | — | | Statin | 2.997 (1.872~4.869) | <0.001 | — | — | — | — | | Uric acid, per 100 μmol/L | 1.528 (1.311~1.786) | <0.001 | 1.351 (1.125~1.625) | 0.001 | / | / | | Quartiles of uric acid, μmol/L | — | — | — | — | — | — | | ≤282 | Ref | — | — | — | Ref | — | | 283~340 | 1.171 (0.809~1.696) | 0.403 | — | — | 0.753 (0.491~1.151) | 0.190 | | 341~ 393 | 1.376 (0.958~ 1.983) | 0.085 | — | — | 0.893 (0.586~ 1.359) | 0.596 | | ≥ 394 | 2.697 (1.892~ 3.867) | <0.001 | — | — | 1.851 (1.215~ 2.828) | 0.004 |
|
|
ACEI: angiotensin-converting enzyme inhibitor; ARB: angiotensin receptor blocker; BMI: body mass index; BP: blood pressure; eGFR: estimated glomerular filtration rate; HbA1c: glycated hemoglobin A1c; HDL: high-density lipoprotein; HOMA-IR: homeostasis model assessment-estimated insulin resistance; LDL: low-density lipoprotein; LVEF: left ventricular ejection fraction; SUA: serum uric acid.
|
