Preoperative Serum Calcitonin Level and Ultrasonographic Characteristics Predict the Risk of Metastatic Medullary Thyroid Carcinoma: Functional Analysis of Calcitonin-Related Genes

Figure 4

Analysis of calcitonin-related genes and functions. (a) Differential expression of CALCA in thyroid cancer tissues and normal tissues. (b) Venn diagrams of 7039 thyroid cancer-associated DEGs and 304 CALCA-associated DEGs. (c) 179 crossover genes were significantly enriched in the cytokine–cytokine receptor interaction pathway. (d) Survival analysis of five cytokine–cytokine receptor interaction pathway-related genes in thyroid cancer; (e) GSEA: KEGG pathways that are associated with differential CALCA expression; and (f) survival AUC curves derived from five cytokine–cytokine receptor interaction pathway-related genes in thyroid cancer.

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