Preoperative Serum Calcitonin Level and Ultrasonographic Characteristics Predict the Risk of Metastatic Medullary Thyroid Carcinoma: Functional Analysis of Calcitonin-Related Genes

Table 1

The relationship between ultrasound characteristics, clinicopathological characteristics, and survival status.

Characteristic	Dead ()	Alive ()
Survival (months), median (IQR)	10 (7, 19)	36 (14.5, 52.75)	0.005
Age, median (IQR)	61 (54, 69)	57.5 (46.5, 67)	0.242
Group, (%)			0.161
Metastasis	9 (9.5%)	36 (37.9%)
Nonmetastasis	4 (4.2%)	46 (48.4%)
Sex, (%)			0.694
Female	5 (5.3%)	40 (42.1%)
Male	8 (8.4%)	42 (44.2%)
Grade, (%)			0.011
I	0 (0%)	32 (33.7%)
II	7 (7.4%)	27 (28.4%)
III	6 (6.3%)	19 (20%)
IV	0 (0%)	4 (4.2%)
T, (%)			0.141
T1	2 (2.1%)	34 (35.8%)
T2	4 (4.2%)	20 (21.1%)
T3	2 (2.1%)	15 (15.8%)
T4	5 (5.3%)	13 (13.7%)
N, (%)			0.376
N0	5 (5.3%)	46 (48.4%)
N1	8 (8.4%)	36 (37.9%)
M, (%)			0.075
M0	10 (10.5%)	77 (81.1%)
M1	3 (3.2%)	5 (5.3%)
Infiltrating range, (%)			0.020
Distant	5 (5.3%)	9 (9.5%)
Localized	3 (3.2%)	44 (46.3%)
Regional	5 (5.3%)	29 (30.5%)
Location, (%)			0.730
Left	9 (9.5%)	49 (51.6%)
Right	4 (4.2%)	33 (34.7%)
Diameter (cm), (%)			0.191
>4	8 (8.4%)	31 (32.6%)
2–4	3 (3.2%)	20 (21.1%)
≤2	2 (2.1%)	31 (32.6%)
Echo, (%)			0.269
High	3 (3.2%)	34 (35.8%)
Low	8 (8.4%)	30 (31.6%)
Mix	2 (2.1%)	18 (18.9%)
Nodule edge, (%)			0.085
Blurry	11 (11.6%)	45 (47.4%)
Clear	2 (2.1%)	37 (38.9%)
Calcification, (%)			0.221
No	5 (5.3%)	50 (52.6%)
Yes	8 (8.4%)	32 (33.7%)
Blood flow, (%)			0.098
I–II	4 (4.2%)	49 (51.6%)
III–IV	9 (9.5%)	33 (34.7%)
Calcitonin, (%)			0.730
<200	4 (4.2%)	33 (34.7%)
≥200	9 (9.5%)	49 (51.6%)