Preoperative Serum Calcitonin Level and Ultrasonographic Characteristics Predict the Risk of Metastatic Medullary Thyroid Carcinoma: Functional Analysis of Calcitonin-Related Genes

Table 2

The relationship between ultrasound characteristics, clinicopathological characteristics, and metastasis status.

Characteristic	Nonmetastasis	Metastasis
Status, (%)			0.161
Alive	46 (48.4%)	36 (37.9%)
Dead	4 (4.2%)	9 (9.5%)
Age, median (IQR)	62 (46.5, 68)	57 (49, 64)	0.410
Sex, (%)			0.001
Female	32 (33.7%)	13 (13.7%)
Male	18 (18.9%)	32 (33.7%)
Grade, (%)			<0.001
I	25 (26.3%)	7 (7.4%)
II	21 (22.1%)	13 (13.7%)
III	4 (4.2%)	21 (22.1%)
IV	0 (0%)	4 (4.2%)
T, (%)			<0.001
T1	29 (30.5%)	7 (7.4%)
T2	12 (12.6%)	12 (12.6%)
T3	7 (7.4%)	10 (10.5%)
T4	2 (2.1%)	16 (16.8%)
N, (%)			<0.001
N0	50 (52.6%)	1 (1.1%)
N1	0 (0%)	44 (46.3%)
M, (%)			0.002
M0	50 (52.6%)	37 (38.9%)
M1	0 (0%)	8 (8.4%)
Infiltrating range, (%)			<0.001
Distant	2 (2.1%)	12 (12.6%)
Localized	47 (49.5%)	0 (0%)
Regional	1 (1.1%)	33 (34.7%)
Location, (%)			0.991
Left	30 (31.6%)	28 (29.5%)
Right	20 (21.1%)	17 (17.9%)
Diameter (cm), (%)			<0.001
>4	9 (9.5%)	30 (31.6%)
≤2	28 (29.5%)	5 (5.3%)
2 to 4	13 (13.7%)	10 (10.5%)
Echo, (%)			0.958
High	20 (21.1%)	17 (17.9%)
Low	20 (21.1%)	18 (18.9%)
Mix	10 (10.5%)	10 (10.5%)
Nodule edge, (%)			0.410
Blurry	27 (28.4%)	29 (30.5%)
Clear	23 (24.2%)	16 (16.8%)
Calcification, (%)			<0.001
No	41 (43.2%)	14 (14.7%)
Yes	9 (9.5%)	31 (32.6%)
Blood flow, (%)			<0.001
I–II	40 (42.1%)	13 (13.7%)
III–IV	10 (10.5%)	32 (33.7%)
Calcitonin, (%)			0.011
<200	26 (27.4%)	11 (11.6%)
≥200	24 (25.3%)	34 (35.8%)