Preoperative Serum Calcitonin Level and Ultrasonographic Characteristics Predict the Risk of Metastatic Medullary Thyroid Carcinoma: Functional Analysis of Calcitonin-Related Genes

Table 3

Univariate and multifactorial COX analyses of the risk of death in patients with medullary thyroid cancer.

Characteristics	Univariate analysis		Multivariate analysis
	Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Sex	1.572 (0.514–4.810)	0.428
Grade	1.806 (1.011–3.226)	0.046	1.130 (0.423–3.013)	0.808
T	1.749 (1.085–2.819)	0.022	2.033 (0.614–6.734)	0.246
N	2.230 (0.725–6.853)	0.162	0.222 (0.032–1.519)	0.125
M	7.957 (2.008–31.531)	0.003	7.942 (1.476–42.721)	0.016
Infiltrating range	1.452 (0.816–2.584)	0.204
Location	1.541 (0.475–5.007)	0.472
Diameter (cm)	2.010 (0.984–4.105)	0.055	0.973 (0.174–5.433)	0.975
Echo	0.586 (0.298–1.153)	0.122	0.744 (0.325–1.706)	0.485
Nodule edge	5.179 (1.145–23.432)	0.033	5.136 (0.949–27.787)	0.057
Calcification	2.438 (0.796–7.463)	0.119	1.858 (0.465–7.431)	0.381
Blood flow	3.405 (1.044–11.111)	0.042	2.794 (0.712–10.959)	0.141
Calcitonin	1.506 (0.463–4.895)	0.496