Aldolase A Promotes Colorectal Cancer Progression through Targeting COPS6 and Regulating MAPK Signaling Pathway

<div>ALDOA was overexpressed in CRC tissues and cell lines. (a) ALDOA, ALDOB, and ALDOC were examined by qRT-PCR in CRC cell lines, and ALDOA occupied the most expression in aldolase family. (b, c) The overexpressed mRNA expression of ALDOA was tested in CRC tissues. (d) Western blotting showed elevated protein expression of ALDOA in CRC tissues. (e) The enzyme activity of ALDOA in CRC tissues was assessed higher level than normal. (f) Upregulation of ALDOA mRNA levels in CRC cell lines (SW620, DLD1, SW480, LoVo, and HCT116) was examined by qRT-PCR. (g) The ALDOA enzymatic activity was evaluated in CRC and normal colon epithelial cell lines. (h) The localization of ALDOA was observed mainly in cytoplasm by IF assay. 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Figure 1

Figure 1: Aldolase A Promotes Colorectal Cancer Progression through Targeting COPS6 and Regulating MAPK Signaling Pathway 