Research Article

Aldolase A Promotes Colorectal Cancer Progression through Targeting COPS6 and Regulating MAPK Signaling Pathway

Figure 4

Overexpressed ALDOA enhanced the proliferation and metastasis of CRC cells. (a, b) The upregulated effect of stable ALDOA overexpression CRC cell lines was identified by qRT-PCR and western blotting analyses. (c) CCK-8 assays showed that upregulation of ALDOA promoted CRC cell proliferation. (d) Overexpressed ALDOA improved the ability of CRC cell proliferation using EdU assays. (e) Wound healing assays demonstrated that increased ALDOA was beneficial to CRC cell migration. (f) Matrigel-transwell and non-Matrigel-transwell assays, respectively, verified that overexpressed ALDOA enhanced the invasion and migration of CRC cells. , , and .
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