Aldolase A Promotes Colorectal Cancer Progression through Targeting COPS6 and Regulating MAPK Signaling Pathway

<div>COPS6 acted as a cancer promoter in CRC. (a) The basal mRNA expression of COPS6 in CRC tissues was tested by qRT-PCR. (b) The protein expression of COPS6 in 12 paired CRC specimens was detected by western blotting. (c) Correlation analysis between COPS6 and ALDOA protein expression in CRC tissues. (d) Correlation analysis of ALDOA with COPS6 based on online databases (cBioPortal for Cancer Genomics, <a href="http://www.cbioportal.org/">http://www.cbioportal.org/</a>). (e) CCK-8 assays were used to evaluate the effect of COPS6 knockdown on the proliferation of SW480 and DLD1. (f) Wound healing assays were performed to assess the migration of CRC cell with COPS6 knockdown. 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Disease Markers

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Figure 7

Figure 7: Aldolase A Promotes Colorectal Cancer Progression through Targeting COPS6 and Regulating MAPK Signaling Pathway 