CEACAM1 Is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Clear Cell Renal Cell Carcinoma

Table 3

Associations between overall survival and clinicopathological characteristics in ccRCC patients by Cox regression.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Age	539
≤60	269	Reference
>60	270	1.765 (1.298-2.398)	<0.001	1.729 (1.128-2.651)	0.012
Gender	539
Female	186	Reference
Male	353	0.930 (0.682-1.268)	0.648
Pathologic stage	536
Stage I and stage II	331	Reference
Stage III and stage IV	205	3.946 (2.872-5.423)	<0.001	1.483 (0.575-3.822)	0.415
Histologic grade	531
G1 and G2	249	Reference
G3 and G4	282	2.702 (1.918-3.807)	<0.001	1.486 (0.891-2.479)	0.129
T status	539
T1 and T2	349	Reference
T3 and T4	190	3.228 (2.382-4.374)	<0.001	1.344 (0.581-3.107)	0.490
N status	257
N0	241	Reference
N1	16	3.453 (1.832-6.508)	<0.001	1.597 (0.797-3.203)	0.187
M status	506
M0	428	Reference
M1	78	4.389 (3.212-5.999)	<0.001	2.291 (1.332-3.939)	0.003
CEACAM1	539
Low	270	Reference
High	269	0.459 (0.336-0.627)	<0.001	0.489 (0.306-0.783)	0.003

T: tumor size; N: lymph node; M: metastasis.