TRIM58 Interacts with ZEB1 to Suppress NSCLC Tumor Malignancy by Promoting ZEB1 Protein Degradation via UPP

Figure 7

Schematic diagram of potential molecular mechanism of tumor inhibitory effects of TRIM58. TRIM58 interacted with ZEB1 and promoted ZEB1 protein degradation via UPP. Decreased ZEB1 promoted tumor cellular malignant biological behavior including cellular proliferation, migration, invasion, and chemoresistance.