Bioinformatics Analysis Identifies EPAS1 as a Novel Prognostic Marker Correlated with Immune Infiltration in Acute Myeloid Leukemia

Figure 4

Enrichment plots from Gene Set Enrichment Analysis (GSEA). Ribosome, SRP-dependent cotranslational protein targeting to membrane, AML with MLL fusions, AML with FLT3-ITD, tretinoin response and PML-RARA fusion, and HDACS deacetylate histones are differentially enriched in low-EPAS1 expression phenotype. Regulation of actin dynamics for phagocytic cup formation, complement cascade, signaling by the B cell receptor, stem cell up, cell surface interactions at the vascular wall, and immunoregulatory interactions between a lymphoid and a nonlymphoid cell are differentially enriched in high-EPAS1 expression phenotype. SRP: signal recognition particle; ITD: internal tandem duplication; HDACS: histone deacetylase; NES: normalized enrichment score; FDR: false discovery rate.

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