Research Article

Transcription Activation of Rab8A by PEA3 Augments Progression of Esophagus Cancer by Activating the Wnt/β-Catenin Signaling Pathway

Figure 2

siRab8A transfection affected the growth, apoptosis, migration, and invasion abilities of KYSE150 and Eca109 cells. (a, b) The OD values of KYSE150 and Eca109 cells were obviously reduced after siRab8A-1 or siRab8A-2 transfection. (c, d) The number of cell clones in KYSE150 and Eca109 cells was obviously reduced after siRab8A-1 or siRab8A-2 transfection. (e–h) siRab8A-1 or siRab8A-2 transfection obviously reduced Bcl-2 and increased BAK and active caspase-3 in KYSE150 and Eca109 cells. (i–l) The number of cell migration and invasion in KYSE150 and Eca109 cells was obviously reduced after siRab8A-1 or siRab8A-2 transfection. vs. control.
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