Research Article

Transcription Activation of Rab8A by PEA3 Augments Progression of Esophagus Cancer by Activating the Wnt/β-Catenin Signaling Pathway

Figure 4

The biological effects of PEA3-OE on KYSE150 and Eca109 cells were counteracted by si-Rab8A. (a–d) The promoting effects of PEA3-OE on OD values and cell clone numbers in KYSE150 and Eca109 cells were reversed by si-Rab8A treatment. (e–h) PEA3-OE treatment increased Bcl-2 expression and decreased Bak and active caspase-3 expression in KYSE150 and Eca109 cells, whereas the phenomena were reversed by the addition of si-Rab8A. (i–l) The increased invasion and migration abilities of KYSE150 and Eca109 cells caused by PEA3-OE were inhibited by the administration of si-Rab8A. vs. control; # and ## vs. PEA3-OE.
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