Tanshinone IIA Inhibits Triple-Negative Breast Cancer Cells MDA-MB-231 via G Protein-Coupled Estrogen Receptor- (GPER-) Dependent Signaling Pathway

Figure 1

Network construction. (a) Common targets screened from Tan IIA and TNBC. (b) Tan IIA-target-TNBC network. Blue circles represent potential targets of Tan IIA for the treatment of TNBC. (c, d) Protein-protein interaction (PPI) network constructed by STRING database and Cytoscape software. In Figure 2(d), the size of the node, its color, and its shade variation represent the magnitude of the degree value. (e) GO enrichment analysis of 39 common targets. adjust represents the significance of enrichment. The redder the color, the higher the enrichment.

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