Integrative Bioinformatics Analysis Identifies DDX60 as a Potential Biomarker for Systemic Lupus Erythematosus

Figure 7

PPI network, heatmap, and correlation matrix of DDX60-related DEGs. (a) PPI network constructed with the DDX60-related DEGs. The green nodes represent upregulated genes, the pink nodes stand for downregulated genes, and the blue node is DDX60. The gradual change of node size from small to big indicates the MCODE score from small to large. (b) The most highly interconnected subcluster separated from the PPI network by the Molecular Complex Detection (MCODE) plug-in according to the MCODE score. The gradual change of node size from small to big indicates the degree value from small to large. (c) Heatmap of the 15 most significantly upregulated (red) and 15 most downregulated (blue) DDX60-related DEGs. (d) Correlation matrix shows the intercorrelation of the 15 most upregulated and 15 downregulated genes. The colors refer to the correlation coefficient magnitude, ranging from positive (red) to negative (green) correlation. Large circles indicate strong correlations, whereas small ones reflect weak correlations.

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