Research Article

Inhibition of Mast Cell Degranulation in Atopic Dermatitis by Celastrol through Suppressing MRGPRX2

Figure 4

The activation of the MRGPRX2/ORAI axis in the atopic dermatitis animal model was suppressed by Celastrol. (a) The expression of MRGPRX2 in the skin tissue was measured with IHC staining. (b) The expression of MRGPRX2 was analyzed. (c) The levels of ORAI-1 and ORAI-2 in the skin tissue were detected with IHC staining. (d) The levels of ORAI-1 and ORAI-2 were analyzed. (e) The expression levels of the MRGPRX2/ORAI axis were measured with western blot; indicates .
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