Determination of Tumor Marker Screening for Lung Cancer Using ROC Curves

Table 2

The value of single tumor marker testing in screening for lung cancer in patients with benign lung lesions and healthy individuals.

	SEN	SPE	PPV	NPV	+LR	−LR	Yden	Cutoff	AUC
Benign lung disease
CEA	0.501	0.690	0.555	0.642	1.61	0.72	0.212	5.625	0.619
CA125	0.346	0.672	0.449	0.571	1.03	0.97	0.154	54.56	0.537
NSE	0.481	0.877	0.752	0.686	3.91	0.59	0.405	13.94	0.695
GRP	0.471	0.805	0.651	0.663	2.41	0.65	0.329	90.01	0.570
CY211	0.511	0.519	0.451	0.579	1.06	0.94	0.232	4.49	0.538
Healthy
CEA	0.500	0.890	0.836	0.616	4.54	0.56	0.448	2.335	0.771
CA125	0.340	0.970	0.927	0.573	11.33	0.68	0.483	14.61	0.729
NSE	0.483	0.880	0.812	0.613	4.02	0.58	0.362	16.42	0.667
GRP	0.469	0.936	0.891	0.614	7.32	0.56	0.395	48.55	0.663
CY211	0.510	0.857	0.798	0.612	3.56	0.57	0.417	3.62	0.713

SEN: sensitivity; SPE: specificity; PPV: positive predictive value; NPV: negative predictive value; +LR: positive likelihood ratio; −LR: negative likelihood ratio; and Yden: Youden index.