Determination of Tumor Marker Screening for Lung Cancer Using ROC Curves

Table 3

Lung cancer screening is performed with the biomarkers in healthy people.

Healthy	SEN	SPE	PPV	NPV	+LR	−LR	Yden	AUC
CEA + CA125^▴	0.601	0.865	0.832	0.661	4.44	0.46	0.523	0.821
CEA + CY211	0.676	0.764	0.761	0.680	2.86	0.424	0.455	0.776
CEA + NSE	0.693	0.794	0.789	0.699	3.36	0.386	0.494	0.798
CEA + GRP	0.730	0.850	0.844	0.739	4.86	0.205	0.561	0.814
CA125 + CY211	0.595	0.835	0.800	0.650	3.57	0.277	0.489	0.733
CA125 + GRP	0.619	0.838	0.888	0.683	3.82	0.261	0.582	0.774
CA125 + NSE	0.585	0.850	0.813	0.648	3.90	0.488	0.516	0.764
CY211 + NSE	0.67	0.752	0.750	0.672	2.68	0.438	0.388	0.678
CY211 + GRP	0.713	0.812	0.809	0.718	3.79	0.353	0.422	0.677
NSE + GRP	0.663	0.831	0.814	0.689	3.92	0.405	0.445	0.694
CEA + CA125 + NSE	0.723	0.767	0.776	0.714	3.10	0.361	0.528	0.829
CEA + CA125 + CY211	0.710	0.741	0.753.	0.697	2.74	0.391	0.523	0.821
CEA + CA125 + GRP	0.760	0.827	0.830	0.756	4.39	0.290	0.607	0.838
CA125 + NSE + GRP	0.723	0.808	0.807	0.724	3.76	0.257	0.562	0.785
CA125 + CY211 + NSE	0.717	0.730	0.747	0.689	2.65	0.387	0.512	0.764
CA125 + CY211 + GRP	0.754	0.794	0.802	0.743	2.79	0.309	0.585	0.776
CEA + CY211 + GRP	0.804	0.730	0.768	0.770	2.97	0.335	0.561	0.816
CEA + CY211 + NSE	0.771	0.674	0.724	0.725	2.36	0.339	0.492	0.797
CEA + NSE + GRP	0.804	0.760	0.788	0.777	3.35	0.257	0.571	0.824
CYF21+NSE + GRP	0.787	0.715	0.754	0.751	2.74	0.297	0.454	0.698
CEA + CA125 + CY211 + NSE	0.787	0.651	0.715	0.734	2.04	0.327	0.528	0.828
CEA + CA125 + CY211 + GRP	0.814	0.711	0.758	0.775	2.86	0.260	0.611	0.838
CA125 + CY211 + NSE + GRP	0.855	0.647	0.751	0.800	2.40	0.224	0.571	0.824
CEA + CY211 + NSE + GRP	0.855	0.647	0.729	0.800	2.42	0.219	0.568	0.785
CEA + CA125 + NSE + GRP	0.814	0.737	0.775	0.781	3.09	0.252	0.614	0.840
CEA + CA125 + CY211 + NSE + GRP^★	0.858	0.629	0.720	0.800	2.31	0.225	0.611	0.840