Determination of Tumor Marker Screening for Lung Cancer Using ROC Curves

Table 8

AUC for various combinations of markers to screen for lung cancer in different populations at different ages.

	Healthy		Benign lung disease
Year	<65	≥65	<65	≥65
CEA	0.746	0.742	0.632	0.640
NSE	0.615	0.726	0.652^c1	0.743^d1
GRP	0.562	0.672	0.568	0.601
CA125	0.694	0.768	0.542	0.549
CEA + NSE	0.762^a1	0.800^b1	0.697^c2	0.759^d2
CEA + GRP	0.785^a2	0.794	0.647	0.685
NSE + GRP	0.644	0.733	0.637	0.729
CEA + CA125	0.785^a3	0.808^b2	0.625	0.644
CA125 + GRP	0.735	0.798	0.585	0.603
CA125 + NSE	0.721	0.800^b3	0.652^c3	0.743^d3

a1 vs a2: Z = 1.202 ; a1 vs a3: Z = 1.445 ; a2 vs a3: Z = 0.004 ; b1 vs b2: Z = 0.256 ; b1 vs b3: Z = 0.007 ; b2 vs b3: Z = 0.455 ; c1 vs c2: Z = 2.973 ; c1 vs c3: Z = 0.076 ; c2 vs c3: Z = 3.005 ; d1vsd2: Z = 1.003; d1 vs d3: Z = 0.097 ; d2 vs d3: Z = 1.007