Plasma microRNA-320c as a Potential Biomarker for the Severity of Knee Osteoarthritis and Regulates cAMP Responsive Element Binding Protein 5 (CREB5) in Chondrocytes

Figure 1

Expression level and diagnostic value of plasma miR-320c in osteoarthritis: (a) the expression levels of plasma miR-320c in the OA groups and control group by qRT-PCR (normalized to U6); (b) correlation of the plasma miR-320c level with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score; (c) receiver operating characteristic (ROC) curve for plasma miR-320c in OA, and the area under the curve (AUC) was 0.942; and (d) ROC curve for plasma miR-320c between moderate and severe OA, and the AUC was 0.985. OA-M: moderate osteoarthritis group and OA-S: severe osteoarthritis group.

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