Angiogenesis and Progression in Human Melanoma

Table 1

Molecular targets of antiangiogenic drugs.

Category	Molecular Targets	Name
Angiogenic growth factors and their receptors	VEGF	Bevacizumab
	Tyrosine kinase receptors	Sorafenib
	VEGF receptors	PTK/ZK
		DC101
Receptors for extracellular matrix, integrins	Integrin 𝛼v𝛽3	Vitaxin (MEDI-52)
	𝛼v𝛽3/𝛼v𝛽5	Cilengitide
		(EMD 121974)
Components of extracellular matrix and proteases	MMPs	Batimastat
		Marimastat
	Extracellular matrix	Endostatin
Complex mechanism of action	Angiogenesis inhibitors and immunomodulators	Thalidomide
		Lenalidomide
	Cyclooxygenase-2	Celecoxib