Dermatology Research and Practice / 2011 / Article / Tab 1 / Review Article
Molecular Nevogenesis Table 1 Congenital melanocytic nevi.
Study Size studied NRAS BRAF Specimen selection Carr and Mackie 1994 [3 ] Totala 12 of 43 n/a Present before age 2 per parent testimony Jafari et al. 1995 [4 ] Totala 1 of 1 n/a Histology alone Papp et al. 1999 [5 ] Total 10 of 18 Histology alone Small 2 of 3 n/a Medium 8 of 15 Pollock et al. 2003 [6 ] Totala n/a 6 of 7 Histology alone Yazdi et al. 2003 [7 ] Totala n/a 6 of 13 Histology alone Papp et al. 2005 [8 ] Totala n/a 7 of 18 Histology alone Da Raeve et al. 2006 [9 ] Total n/a 0 of 36 Documented in medical records at birth Medium 0 of 10 Large 0 of 26 Ichii-Nakata et al. 2006 [10 ] Total 9 of 20 39 of 62 Documented in medical records at birth per parent testimony Small n/a 33 of 42 Medium 9 of 20 6 of 20 Bauer et al. 2007 [11 ] Totalb 26 of 32 0 of 32 Documented in medical records at birth Bauer et al. 2007 [11 ] Totalc,d 7 of 28 20 of 28 Histology alone Wu et al. 2007 [12 ] Total n/a 26 of 34 Documented in medical records at birth Small 20 of 25 Large 6 of 9 Total 19 of 27 6 of 27 Documented in medical records at birth Dessars et al. 2009 [13 ] Medium 1 of 3 1 of 3 Large 18 of 24 5 of 24e Totals Total 77 of 141 (54.6%) 90 of 229 (39.3%) Small n/a 53 of 67 (79.1%) Medium and Large 62 of 94 (65.9%) 18 of 124 (14.5%)
(a) Size of specimens not specified; (b) all specimens either medium or large CMN; (c) all specimens small CMN; (d) not included in totals because purposely selected for acquired nevi with congenital patterns; and (e) two of the five represent chromosomal translocation involving BRAF.