Retrospective Analysis of Corticosteroid Treatment in Stevens-Johnson Syndrome and/or Toxic Epidermal Necrolysis over a Period of 10 Years in Vajira Hospital, Navamindradhiraj University, Bangkok

Table 3

Comparison of incidences of culprit drugs.

	2008–2012; (𝑛=58), 𝑛 (%)	2003–2007; (𝑛=42), 𝑛 (%)	𝑃 value
Antibiotics	26 (44.8)	14 (33.3)	0.265
Penicillin	7 (12.1)	4 (9.5)	0.718
Cotrimoxazole	7 (12.1)	4 (9.5)	0.718
Cephalosporin	5 (8.6)	2 (4.8)	0.473
Quinolone	3 (5.2)	2 (4.8)	0.949
Carbapenem	2 (3.4)	0 (0)	0.229
Clindamycin	1 (1.7)	0 (0)	0.398
Tetracycline	1 (1.7)	0 (0)	0.398
Macrolide	0 (0)	2 (4.8)	0.089
Anticonvulsants	14 (24.1)	4 (9.5)	0.064
Phenytoin	8 (13.8)	3 (7.1)	0.309
Carbamazepine	4 (6.9)	1 (2.4)	0.317
Phenobarbital	1 (1.7)	0 (0)	0.398
Lamotrigine	1 (1.7)	0 (0)	0.398
Allopurinol	7 (12.1)	8 (19.1)	0.301
NSAIDs	5 (8.6)	4 (9.5)	0.844
Nevirapine	3 (5.2)	4 (9.5)	0.377
Antituberculosis^a	3 (5.2)	0 (0)	0.139
Other drugs	0 (0)	8 (19.1)
TTM	0 (0)	2 (4.8)	0.089
Valacyclovir	0 (0)	2 (4.8)	0.089
Cetirizine	0 (0)	1 (2.4)	0.231
Chloroquine	0 (0)	1 (2.4)	0.231
Cinnarizine	0 (0)	1 (2.4)	0.231
Silymarin	0 (0)	1 (2.4)	0.231

^aAntituberculosis (isoniazid, rifampicin, pyrazinamide, and ethambutol).
NSAIDs: nonsteroidal anti-inflammatory drugs.
TTM: traditional Thai medicine.