Impaired Healing of a Cutaneous Wound in an Inducible Nitric Oxide Synthase-Knockout Mouse

Figure 7

Expression of mRNA of α-smooth muscle actin (αSMA), F4/80, transforming growth factor β1 (TGFβ1), and collagen 1α2 in healing tissues of wild type (WT) and inducible nitric oxide synthase (iNOS-) knockout (KO) mice at days 3, 6, and 8. (a) F4/80 mRNA expression was significantly more suppressed in KO tissues at day 6 as compared with WT tissues. (b) Expression of TGFβ1 mRNA was significantly attenuated in KO tissues as compared with WT tissues at days 6 and 8. (c) Expression of αSMA mRNA was significantly less marked in KO tissues at day 8 as compared with WT tissues. (d) Collagen 1α2 mRNA expression was reduced in KO tissues as compared with WT tissues at days 3 and 8 with statistically significant difference. Open bars: WT, filled bars: KO. Mean ± standard deviation. ; n.s., not significant.

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