Gut Microbiota and Depressive Symptoms at the End of CRT for Rectal Cancer: A Cross-Sectional Pilot Study

Table 4

Statistically significant correlations between MetaCyc pathway abundances and the Hamilton Depression Rating Scale scores at the end-CRT samples.

MetaCyc pathway	End-CRT
	Rho	value
Acetyl-CoA fermentation to butanoate II	-0.37	0.02
Chondroitin sulfate degradation I (bacterial)	-0.33	0.04
CMP-legionaminate biosynthesis I	-0.41	0.009
Flavin biosynthesis I (bacteria and plants)	-0.36	0.02
Inosine-5-phosphate biosynthesis III	0.33	0.04
GDP-mannose biosynthesis	-0.33	0.04
L-methionine biosynthesis I	0.36	0.02
L-methionine biosynthesis III	0.42	0.007
Mono-trans, poly-cis decaprenyl phosphate biosynthesis	0.36	0.02
Myo-, chiro-, and scyllo-inositol degradation	-0.39	0.01
Phosphopantothenate biosynthesis I	-0.39	0.02
Superpathway of coenzyme A biosynthesis I (bacteria)	-0.42	0.007
Superpathway of L-alanine biosynthesis	0.36	0.02
Superpathway of S-adenosyl-L-methionine biosynthesis	0.33	0.04

CRT = chemotherapy and radiation therapy.