Analyzing Differences in Diagnostic Accuracy of a Pigmented Lesion Assay for Melanoma

Table 3

Diagnostic accuracy in the total and biopsied cohort.

Total cohorts	Melanoma	Nonmelanoma	Total		Biopsied cohort	Melanoma	Nonmelanoma	Total
PLA +	14	42	56		PLA +	14	42	56
PLA −	5	365	370		PLA −	5	35	40
Total	19	407	426		Total	19	77	96
Estimate		Standard error (SE)	95% lower CI	95% upper CI	Estimate		Standard error (SE)	95% lower CI	95% upper CI
Accuracy	89.0%	0.02	86.0%	91.9%	Accuracy	51.0%	0.05	41.0%	61.0%
Sens	73.7%	0.10	53.9%	93.5%	Sens	73.7%	0.10	53.9%	93.5%
Spec	89.7%	0.02	86.7%	92.6%	Spec	45.5%	0.06	34.3%	56.6%
Prevalence	4.5%	0.01	2.5%	6.4%	Prevalence	19.8%	0.04	11.8%	27.8%
PPV	25.0%	0.06	13.7%	36.3%	PPV	25.0%	0.06	13.7%	36.3%
NPV	98.6%	0.01	97.5%	99.8%	NPV	87.5%	0.05	77.3%	97.7%
Kappa	0.329				Kappa	0.110