Physical Treatment of Diabetic Foot Ulcers—Preliminary Study for Topical Application of Oxygen or Ozone Auxiliary Treatment of Diabetic Foot Ulcers

Table 2

Comparison of the surface area of treated ulcers and the pain intensity in both the groups of patients before and after the end of the therapeutic cycle, taking into account the duration of the disease.

	Topical oxygen therapy			Topical ozone therapy
	1–3 years (n = 26) mean ± SD	4–6 years (n = 17) mean ± SD	p	1–3 years (n = 16) mean ± SD	4–6 years (n = 26) mean ± SD
Ulcer surface area (cm^2) before treatment	6.11 ± 1.19	7.30 ± 0.89	<0.001	6.69 ± 1.18	8.11 ± 0.84	<0.001
Ulcer surface area (cm^2) after treatment	4.01 ± 1.18	5.00 ± 1.18	0.015	4.55 ± 1.25	6.33 ± 1.54	<0.001
% change of ulcer surface area after treatment	35.32 ± 9.94	31.98 ± 11.56	0.376	32.41 ± 12.85	22.95 ± 15.29	0.015
VAS score (points) before treatment	7.56 ± 0.72	8.07 ± 0.68	0.034	7.80 ± 0.98	8.11 ± 0.85	0.262
VAS score (points) after treatment	2.56 ± 1.15	3.92 ± 1.23	<0.001	4.69 ± 1.22	4.76 ± 1.14	0.951
% change of VAS score after treatment	66.14 ± 14.89	51.58 ± 14.68	<0.001	39.85 ± 14.72	40.77 ± 14.66	0.893