Hyaluronic Acid Dissolving Microneedles and Nonablative Fractional Laser for Infraorbital Wrinkles: A Prospective, Randomized, Split-Face Study
Table 1
Scores, proportions, and durations of adverse effects on two sides.
Adverse effect
Scores
Proportion (%)
Duration
HA-DMNs
NAFL
value
HA-DMNs
NAFL
HA-DMNs
NAFL
Pain
1.5 (0.0, 2.8)
1.5 (0.3, 2.0)
0.88
60.71
75.00
2–10 min
1–24 h
Pruritus
0.0 (0.0, 0.0)
0.0 (0.0, 0.0)
>0.99
14.29
10.71
12–72 h
48 h
Burning
0.0 (0.0, 0.0)
0.0 (0.0, 1.0)
0.01
7.14
42.86
5–12 min
12–24 h
Erythema
0.0 (0.0, 1.0)
1.0 (1.0, 1.0)
<0.01
35.71
100.00
12–48 h
8–72 h
Edema
0.0 (0.0, 0.8)
1.0 (1.0, 1.0)
<0.01
25.00
82.14
12–72 h
12–72 h
Desquamation
0.0 (0.0, 0.0)
0.0 (0.0, 0.0)
0.50
0.00
7.14
—
1–24 h
Crust
0.0 (0.0, 0.0)
0.0 (0.0, 1.0)
<0.01
0.00
39.29
—
1–10 d
The scores are shown as median (p25, p75). HA-DMNs: hyaluronic acid dissolving microneedles. NAFL: nonablative fractional laser. Duration on HA-DMNs side refers to the duration of different adverse effects with each use.
