Review Article
Comparison of Cryotherapy and Topical Salicylic Acid in Common Warts: A Systematic Review and Meta-Analysis
Table 2
Interventions and outcomes of the included studies.
| | Study | Year | Treatment | Duration | Percentage recovered | Side effect | Recurrence rate (%) | Outcomes | | Cryotherapy | Salicylic acid | Cryotherapy | Salicylic acid | Cryotherapy | Salicylic acid | Cryotherapy | Salicylic acid | Cryotherapy | Salicylic acid |
| | Bunney | 1976 | 4-5 sessions | Daily self-application of SA/LA paint for 12 weeks | 3 weeks apart | Daily up to a maximum of 12 weeks | 67.3 | 68.6 | — | — | — | — | Cure rate at 12 weeks | | Steele | 1988 | Up to 6 sessions | Daily self-application of SA/LA paint for 12 weeks | 1 week apart | Daily up to a maximum of 12 weeks | Hand warts = 62.5 | Hand warts = 60.5 | — | — | 0/66 (0%) | 2/60 (3.33%) | Cure rate at 6 months | | Plantar warts = 57.7 | Plantar warts = 40.9 | | Bruggink | 2010 | Up to 6 sessions | Patient self-application with 40% SA | Once every 2 weeks | Daily until warts are completely gone | 39 | 24 | 2/80 | 9/84 | — | — | Complete clearance rate at 13 weeks | | Cockayne | 2011 | Up to 4 sessions | Patient self-application with 50% SA | 2-3 weeks apart | Daily up to a maximum of 8 weeks | 13.6 | 14.3 | 14/28 | 13/28 | 2/117 (1.7%) | 2/123 (1.6%) | Complete clearance rate at 12 weeks | | Rosniza | 2017 | Maximum of 4 sessions | Self-application of 20% SA | 2 weeks apart | Daily up to a maximum of 12 weeks | 33.3 | 26.8 | — | — | — | — | Complete clearance rate at 12 weeks | | Muhamad | 2018 | Up to 5 sessions | Self-application with 40% SA | 2-3 weeks apart | Daily up to a maximum of 8 weeks | 66.7 | 80 | — | — | — | — | Complete clearance rate at 12 weeks | | Qamar | 2018 | Up to 3 sessions | Self-application of 40% SA | 2 weeks apart | Daily up to a maximum 6 weeks | 56.9 | 66.7 | — | — | — | — | Complete clearance rate at 6 weeks |
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SA/LA = salicylic acid/lactic acid; SA = salicylic acid.
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