Unique Retinol Therapy with Antioxidant and Anti-Inflammaging Complex for Naturally Reborn Skin: The Clinical Case Series Study
Table 2
Skin pigmentation reduction during the therapy, with a statistically significant difference in group S.
P (n = 5)
S (n = 5)
NSS (n = 5)
Summary (n = 15)
Test 1
Mean (SD)
12.4 (2.2)
12.8 (2.6)
13.2 (1.7)
12.8 (2.1)
Range
10.8–15.5
8.5–14.7
11.5–15.3
8.5–15.5
Median
11.0
14.3a
12.3
12.3a,b
95% CI
[9.7; 15.0]
[9.6; 16.1]
[11.0; 15.3]
[11.6; 13.9]
Test 2
Mean (SD)
12.3 (2.9)
11.5 (2.8)
13.0 (0.9)
12.3 (2.3)
Range
9.7–16.0
7.0–14.7
11.7–14.3
7.0–16.0
Median
10.7
11.8
13.0
12.3c
95% CI
[8.7; 16.0]
[8.0; 14.9]
[11.8; 14.2]
[11.0; 13.6]
Test 3
Mean (SD)
11.7 (2.8)
10.9 (1.7)
10.9 (1.2)
11.2 (1.9)
Range
8.5–14.7
8.3–12.3
9.5–12.3
8.3–14.7
Median
11.7
11.0
11.0
11.0
95% CI
[8.2; 15.2]
[8.8; 13.0]
[9.3; 12.4]
[10.1; 12.2]
Test 4
Mean (SD)
11.5 (2.3)
10.6 (1.4)
10.3 (1.6)
10.7 (1.7)
Range
9.5–14.3
9.5–13.0
7.8–11.7
7.8–14.3
Median
11.1
10.0
10.3
10.2a
95% CI
[7.8; 15.2]
[8.8; 12.4]
[8.3; 12.2]
[9.8; 11.7]
Test 5
Mean (SD)
11.1 (2.5)
9.5 (2.3)
9.2 (2.0)
10.0 (2.3)
Range
8.3–13.7
5.7–12.0
7.3–12.0
5.7–13.7
Median
11.7
10.0a
8.5
10.0b,c
95% CI
[8.0; 14.3]
[6.6; 12.4]
[6.7; 11.7]
[8.7; 11.2]
value
0.37932
0.02212
>0.052
<0.00012
a<0.053
a–c<0.053
P: patients with superficial and deep hyperpigmentation, S: patients with mature skin with first signs of aging, NSS: patients with postinflammatory hyperpigmentation, atrophic acne scars, and enlarged pores.
