Evaluation of E-Cadherin Expression in Patients with Pemphigus Vulgaris via Immunohistochemistry

Figure 1

(a) Normal skin showing strong (3+) membraneous staining of E-cadherin (×400). (b) Suprabasal blister with acantholysis. The blister floor shows weak (2+) staining and the blister roof has a normal 3+ staining pattern (×400). (c) Suprabasal blister of pemphigus vulgaris with loss of E-cadherin expression in the floor of the blister in some parts and 1+ staining in the blister roof (×400). (d) Follicular epithelium in a case of pemphigus vulgaris shows suprabasal weak (1+) E-cadherin expression and 2+ membranous staining in upper layers (same as surface epithelium in this case), ×400. (e) Oral mucosa biopsy in a case of pemphigus shows 1+ basal and suprabasal staining of E-cadherin and 2+ staining in the upper layers of the epithelium (×400).

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