Review Article

Risk of Schizophrenia in Patients with Psoriasis: A Systematic Review and Meta-Analysis

Table 1

Main characteristics of the 8 included studies (2010–2019), based on the Newcastle-Ottawa quality assessment scale.

References; year of publicationCountryStudy designSampleDiagnosis time/age/duration of psoriasisSubjectConfounder adjustmentQuality assessment (Newcastle-Ottawa Score)

Ahn et al. [27]; 2019KoreaCross-sectional study182,127 (42,641 diagnosis/139,486 comparison) including 21,899 children (<18)Not mentionedDiagnosis: patients with psoriasis were identified from the Korean National Health Insurance Research Database in 2015Age, genderSelection: 3 comparability: 1 outcome: 3
Comparison: sex and age-matched comparisons without psoriasis were randomly selected from the same database

Kara et al. [16]; 2019TurkeyCase-control study108 (54 cases/54 controls) including 215 children (<18)Diagnosis duration of psoriasis: at least 3 monthsCases: patients with psoriasis were identified from the University of Health Sciences, Bakirkoy Dr. Sadi Konuk Training and Research Hospital Dermatology DepartmentAge, gender, and comorbiditiesSelection: 3 comparability: 2 outcome: 3
Controls: sex and age-matched controls without psoriasis were randomly selected from the same department

Leisner et al. [29]; 2019DenmarkCase-control study154,715 (13,675 cases/141,040 controls) including 76,980 female adults; 78,400 male adults; and 7,297 children (<18)Diagnosis age of psoriasis:Cases: patients with psoriasis identified from all Danish hospitals between 1900 and 1995Age, gender, birth year, age at first psoriasis diagnosis, education, and comorbiditiesSelection: 3 comparability: 2 outcome: 3
0–19;Controls: sex and age-matched controls without psoriasis were randomly selected from the same hospital
20–39;
40–59;
60–79;
≥80

Raikhy et al. [22]; 2017IndiaCase-control study1,089 (89 cases/1,000 controls)Not mentionedCases: patients with psoriasis identified from Psychiatry Department of NIMS Medical CollegeAge, gender, marital status, religion, education, and occupationSelection: 3 comparability: 2 outcome: 3
Controls: sex and age-matched controls without psoriasis were randomly selected from the same department

Tu et al. [21]; 2017TaiwanCross-sectional study778,123 (10,796 diagnosis/767,327 comparison) including 403,565 female adults; 379,532 male adultsDiagnosis time: with psoriasis during the period from January 1, 1997 to December 31, 2010Diagnosis: patients with psoriasis identified from Taiwan’s National Health Insurance Research DatabaseAge, gender, comorbidities, and durationSelection: 3 comparability: 1 outcome: 3
Comparison: sex and age-matched comparisons without psoriasis were randomly selected from the same database

Patel et al. [28]; 2019USACase-control study87,053,095 (188,089 cases/86,865,066 controls) including 53,907,819 female adults; 38,341,356 male adults; and 15,004,737 children (<18)Diagnosis duration of psoriasis: 5–10 yearsCases: patients with psoriasis identified from the National Inpatient Sample of all US hospitalizations between 2002 and 2012Age, gender, and raceSelection: 3 comparability: 2 outcome: 3
>10 yearsControls: sex and age-matched controls without psoriasis were randomly selected from the same sample

Parisi et al. [15]; 2017U.K.Cohort-comparison study933,880 (56,961 patients/876,919 comparison)Not mentionedCohort: patients with psoriasis identified from the Clinical Practice Research Datalink linked to Hospital Episode Statistics and the Office for National Statistics mortality records in England between 1998 and 2014Age, sex, and general practiceSelection: 3 comparability: 1 outcome: 3
Comparison: sex and age-matched controls without psoriasis were randomly selected from the same cohort

Schmitt and Ford [14]; 2010GermanyCase-control study6294 (3,147 cases/3,147 controls) including 3,528 female adults; 6,377 male adultsNot mentionedCases: patients with psoriasis identified from an interdisciplinary administrative healthcare databaseAge, sex, personal income, and comorbiditiesSelection: 3 comparability: 2 outcome: 3
Controls: sex and age-matched controls without psoriasis were randomly selected from the same cohort