Is Tranexamic Acid Use Effective in Preventing Postinflammatory Hyperpigmentation after Laser Treatment? A Systematic Review and Meta-Analysis

Table 2

TXA application and laser parameters of the included studies.

Study	TXA application			Laser parameters
	Usage	Dosage or concentration	Times/duration	Laser modality	Wavelength	Spot size or scanning area	Output power or fluence	Times	Interval time
Tawfic et al. (1)	Topical	10%	Once	Fractional CO2 laser	10,600 nm	NM	12 Watts	5	4–6 w
Tawfic et al. (2)	Injection	100 mg	Once	Fractional CO2 laser	10,600 nm	NM	12 Watts	5	4–6 w
Wanitphakdeedecha et al.	Topical	1.2%	Once	FTL	1,927 nm	100 μm	5 mJ	4	1 w
Sirithanabadeekul and Srieakpanit	Injection	1.5 mg	Once	QSNYL	532 nm	1.8 mm	0.6–0.8 J/m^2	1	NM
Laothaworn and Juntongjin	Topical	3%	Once daily/8 w	QSNYL	1,064 nm	6 mm	2.0–3.0 J/cm^2	2	4 w
Rutnin et al.	Oral	1500 mg	Twice daily/6 w	QSNYL	532 nm	3 mm	1.8–2.3 J/cm^2	1	NM
Shin et al.	Oral	750 mg	Twice daily/8 w	QSNYL	1,064 nm	7 mm	2.0 J/cm^2	2	4 w
Laothaworn, et al.	Topical	NM	Once	QSNYL	1,064 nm	NM	NM	2	4 w

QSNYL, Q-switched Nd : YAG laser; FLT, fractional thulium fiber laser; w, weeks; NM, not mentioned.